Last updated: 2/21/2019
According to reports in the medical literature, in most individuals with Werner syndrome, the appearance of premature aging is apparent by approximately age 30 to 40.Werner syndrome is also typically characterized by the premature onset of senile cataracts, a condition in which there is loss of transparency of the lenses of the eyes.
Noninsulin-dependent diabetes Figure 2. Werner Syndrome. Skin of the arms and legs may develop abnormally increased coloration (hyperpigmentation), decreased coloration (hypopigmentation), or abnormal widening of certain small underlying blood vessels, causing associated redness (telangiectasias). Seattle (WA): University of Washington, Seattle; 1993-2017. Breast cancer Such findings (sometimes referred to as “variegated translocation mosaicism”) suggest that “chromosome breakage” may be characteristic of or play some role in the disease process. Pp.
In: Pagon RA, Bird TD, Dolan CR, et al., editors. Beaked nose Werner syndrome is a condition that causes premature aging. Visit the 2013; 13: 475-81.Yu CE, Oshima J, Fu YH et al. The in-depth resources contain medical and scientific language that may be hard to understand. Rocker bottom feet
The loss of elasticity of the skin leads to an aged wrinkled appearance. Deep ulcerations around Achilles tendons and, less frequently, at elbows, are highly characteristic to Werner syndrome.Many individuals with Werner syndrome also have additional skin abnormalities.
Get the latest public health information from CDC: Voice abnormality 2009 Feb 10. . However, the disorder often may not be recognized or confirmed until the third or fourth decades of life, once certain distinctive symptoms and findings are noted (e.g., premature graying and hair loss, distinctive voice, loss of subcutaneous tissue, muscular atrophy, skin changes, bilateral senile cataracts, etc. Many of these cases have occurred in Japan, where a On the episode "Stargazer in a Puddle" from the television series James, William; Berger, Timothy; Elston, Dirk (2005). Flattened and twisted hair
Abnormality of the cerebral blood vessels
Affected individuals may have no apparent symptoms (asymptomatic) at diagnosis or experience increased urination (polyuria), excessive thirst (polydipsia), increased hunger (polyphagia), and/or other characteristic symptoms. Gerontology 2014; 60: 239-46.Croteau DL, Popuri V, Opresko PL, Bohr VA. Human RecQ helicases in DNA repair, recombination, and replication. Other symptoms may include underdeveloped teeth and nails, unusually small hands and feet, malformed or missing thumbs, and/or sparse and prematurely gray hair or baldness.
In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K, editors.
Narrowing and hardening of arteries Type 2 diabetes Decreased width of face Premature aged appearance Les symptômes apparaissent entre 20 et 30 ans : cataracte bilatérale, cheveux prématurément gris et fins, petite taille et changements cutanés (ulcère de la cheville, hyperkératose, peau tendue, taches de vieillesse, visage d'oiseau et atrophie sous-cutanée). The hands and feet remain abnormally small into adulthood.
A health care provider may consider these conditions in the table below when making a diagnosis.